The article examines the collaboration between the Earth Science Museum and professors from the Faculty of Biology and the Faculty of Soil Science at Lomonosov Moscow State University (Faculty of Biology and Soil Science until 1973) from the museum’s founding to the present day. In the early 1950s, university professors collaborated with the museum staff to create biology-themed exhibits at the Museum. In particular, they helped preparing the exhibits on the 26th floor (Marine Hall) and the 25th floor (Natural Zonation). A brief overview of the current course offerings in biological disciplines at the Earth Science Museum is presented, including courses for students from the Faculty of Biology, the Faculty of Geology, and the Faculty of Philology at Moscow State University. The disciplines covered include “Ecology”, “Marine Communities and Ecosystems”, “Ecology with Fundamentals of Biogeography”, and “Modern Natural Sciences”. The museum’s exhibition serves as a unique educational environment for such classes, particularly when incorporating modern pedagogical approaches such as the flipped classroom model. The article presents the collaborative work of the Museum’s staff and students from the Faculty of Biology within the framework of the MSU’s Development Program “Development of the Foundations for the Establishing, Operating, and Advancing a Comprehensive University-based Scientific and Educational Youth Museum Using the Example of Lomonosov Moscow State University.” It also highlights the creation of a unique interdisciplinary open-air exhibition at the MSU Botanical Garden on Leninskie gory named “From the Arctic to Moscow: The Path of Glaciers”.