The paper considers the use of two pedagogical approaches, person-centered and systemic-structural, in the development and implementation of two thematic museum classes dedicated to V.I. Vernadsky’s life and scientific activities. These classes, namely, “From the soil to the biosphere” and “V.I. Vernadsky’s life and scientific activity”, were developed at the Earth Science Museum of the Lomonosov Moscow State University and aimed at in-depth acquaintance of schoolchildren with the teaching about the biosphere. The paper presents methodological materials for the classes: a description of the stages of the lessons and tasks for independent work (a crossword and a quest). Our analysis of the second lesson’s approbation showed that the schoolchildren were unanimous in their opinion: the organization of an independent search for answers to the posed questions and the leading role of the museum teacher allowed them to better accepting complex concepts and understanding the relationship of various scientific directions.

The article presents a retrospective analysis of the development of educational and enlightenment activities in the Earth Science Museum of Moscow State University named after Lomonosov from the moment of its foundation to the present. The following trends are highlighted: expansion of the forms and methods of museum pedagogy over time, introduction of interactive methods in the practice of the educational and enlightenment activities, work with various age visitor groups (from younger pupils and students to adults), as well as the use of digital methods in the educational process.

The article discusses various forms of local history activities to be implemented in the interaction of natural science museums and secondary schools. The practical experience of employees of the Earth Science Museum of Lomonosov Moscow State University in the field of local history is described, namely: conducting a professional development program (Summer School), thematic classes with students, and consultations on the creation of educational expositions in school museums. A thematic plan of the section “Nature of the Native land” in a school museum is given. The prerequisites for successful cooperation between natural science museums and secondary schools in the joint implementation of local history activities are substantiated.

The article analyzes approaches to the development and conduct of excursions for students of the early twentieth century and provides recommendations already expressed a hundred years ago for guides and teachers. It was then that two main approaches were distinguished, namely: orientation to listeners (excursionists) and the guide’s detailed knowledge of the museum’s objects. Currently, the preparation of excursions to both the Natural science museum and the botanical garden is almost the same and includes the same stages: from choosing a topic to developing a detailed plan. But botanical garden excursions differ from museum ones, as they have a seasonal nature and depends on the flowering period of the plants. However, all excursions (in a museum or in a botanical garden) perform the same functions, namely: informational, cultural, educational and leisure, although in terms of the degree of impact on human feelings, undoubtedly, botanical garden excursions differ significantly from museum excursions.