This article continues the series of publications on the indicators of Holocene activation. Using the examples of the Volga and Amur rivers with their tributaries and the Razdolnaya River, the interaction of the river network with the Holocene orogenic system of the Alpine–Himalayan and Pacific mobile belts of Eurasia was studied. The river network is conformal to their orogenic system. Examples of the control of river valleys by shear systems of active faults are given. The influence of the rivers on the formation of erosional relief was studied. It is shown that loose sediments of the Mesozoic-Cenozoic rifts thrown up in the Holocene are actively destroyed by the river network, with a shear of up to many hundreds of meters. The rises on the riftogen framing and their internal rises, composed of strong pre-Mesozoic rocks, are weakly eroded. Many of them have a contrasting, nonequilibrium relief. The study was conducted within the framework of the pulsatingly expanding Earth model developed by the author.