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10.29003/m5046.0514-7468.2026_48_1/46-57

EDN INBPXG

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Цао Б., Чивкунова О.Б., Федоренко Т.А., Соловченко А.Е., Лобакова Е.С., Олескин А.В.

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экотоксиканты, нейротрансмиттеры, серотонин, гистамин, норадреналин, дофамин, ацетилхолин, микроводоросли, возрастные стадии культур микроводорослей

экотоксиканты, нейротрансмиттеры, серотонин, гистамин, норадреналин, дофамин, ацетилхолин, микроводоросли, возрастные стадии культур микроводорослей

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С. 46–57

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Цао Боян, Чивкунова О.Б., Соловченко А.Е., Лобакова Е.С., Олескин А.В. Нейрохимические поллютанты в водных экосистемах: механизмы взаимодействия с микроводорослями // Жизнь Земли. 2026. Т. 48, № 1. С. 46–57. DOI: 10.29003/m5046.0514-7468.2026_48_1/46-57.

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Нейрохимические поллютанты в водных экосистемах: механизмы взаимодействия с микроводорослями

03.04.2026

Цао Боян1, Чивкунова Ольга Борисовна2, Федоренко Татьяна Александровна3, Соловченко Алексей Евгеньевич4, Лобакова Елена Сергеевна5, Олескин Александр Владимирович6
1 аспирант / кафедра общей экологии и гидробиологии, биологический факультет МГУ имени М.В. Ломоносова; МГУ-ППИ (Шэньчжэнь, Китай) 2 к.б.н., с.н.с / кафедра биоинженерии, биологический факультет МГУ имени М.В. Ломоносова 3 к.б.н., с.н.с / кафедра биоинженерии, биологический факультет МГУ4 д.б.н., проф / кафедра биоинженерии, биологический факультет МГУ 5 д.б.н., проф / кафедра биоинженерии, биологический факультет МГУ6 д.б.н., проф / кафедра общей экологии и гидробиологии, биологический факультет МГУ имени М.В. Ломоносова

В предшествующей статье в журнале «Жизнь Земли» [7] были рассмотрены нейроактивные вещества как поллютанты нового поколения – на примерах нейротрансмитеров, таких как ацетилхолин и биогенные амины. Данные вещества при низких концентрациях вызывают стимуляторные ростовые эффекты у микроводорослей. В настоящей статье обсуждаются механизмы действия нейротрансмиттеров даже в «следовых» количествах, а именно, антиоксидантное действие и влияние на динамику и ритмику развития микроводорослей – на смену их «возрастных» стадий. Испытанные нейротрансмиттеры, которые могут поступать в природные экосистемы со стоками пищевой, фармацевтической и косметической индустрии, можно подразделить на две подгруппы: 1) вещества, которые увеличивают содержание ненасыщенных жирных кислот (НЖК) в мембранах микроводорослей, повышают концентрацию фотосинтетических пигментов в клетках и, предположительно, продлевают ранние стадии культуры микроводорослей, и 2) вещества, снижающие содержание НЖК в мембранных липидах, уменьшающие концентрацию фотосинтетических пигментов и, соответственно, ускоряющие достижение поздних стадий культуры.

References

Список литературы

Список литературы

  1. Golovlev, E.L., “Academician N.D. Yerusalimsky”, Microbiology (Moscow) 68(6), 800–808 (in Russian).
  2. Yerusalimsky, N.D., Physiology of Development of Pure Cultures. Dr. Sci. Biol. Thesis (Moscow: Institute of Microbiology of the USSR Academy of Sciences, 1952) (in Russian).
  3. Maryin, V.A., Kharitonov, D.V., “Study on the sequence of growth phases in the batch cultures of bifidobacteria or lactobacteria”, Technique and Technology 19(4) (2010)(in Russian).
  4. Feofilova, E.P., Mysiakina, I.S., Biofuel: problems and prospects (Moscow: National Academy of Mycology, 2016) (in Russian).
  5. Tsavkelova, E.A., Klimova, S.Yu., Cherdyntseva, T.A., Netrusov, A.I., “Microorganisms producing plant growth stimulants: practical applications (a review)”, Appl. Biochem. Microbiol. 42(2), 133–143 (2006) (in Russian).
  6. Tsavkelova, E.A., Klimova, S.Yu., Cherdyntseva, T.A., Netrusov, A.I.,“Hormones and hormone-like compounds of microorganisms (a review)”, Appl. Biochem. Microbiol. 42(3), 261–268 (2006) (in Russian).
  7. Cao, B., Oleskin, A.V.,“Neurochemical pollutants in the aquatic medium: the results of studies with model organisms (microalgae)”, Zhizn Zemli [Life on the Earth] 47(4), 26–40 (2025). DOI: 10.29003/м28.0514-7468.
  8. Cao, B., Chivkunova, O.B., Solovchenko, A.E., Lobakova, E.S., Oleskin, A.V.,“Impact of neurotransmitters on the fatty acid composition and pigments of the green microalga Scenedesmus quadricauda”, Appl. Biochem. Microbiol. 60(5), 833–843 (2024). DOI: 10.1134/S0003683824604554.
  9. Cao, B., Fedorenko, T.A., Chivkunova, O.B., Solovchenko, A.E., Lobakova, E.S., Oleskin, A.V.,“Impact of neurotransmitters on the photosynthetic pigment content of the green microalga Haematococcus lacustris (strains IPPAS H-239 and BM-1)”, Appl. Biochem. Microbiol. 61(5), 865–871 (2025). DOI: 10.1134/S0003683825601155.
  10. Cao, B., Fedorenko, T.A., Chivkunova, O.B., Solovchenko, A.E., Lobakova, E.S., Oleskin, A.V., “Impact of neurotransmitters on biomass accumulation, photosynthetic pigment content, and fatty acid composition of the cyanobacterium Limnospira platensis IPPAS B-256”, Microbiology (Moscow) 95 (1), 82-95 (2026). DOI: 10.1134/S0026261725602921.
  11. Chekanov, K., Lobakova, E., Selyakh, I., Semenova, L., Sidorov, R., Solovchenko, A.,“Accumulation of astaxanthin by a new Haematococcus pluvialis strain BM1 from the White Sea coastal rocks (Russia)”, Mar Drugs. 12(8), 4504–4520 (2014). DOI: 10.3390/md12084504.
  12. Czerpak, R., Bajguz, A., Jewiec, P., Muszynska-Garstka, M., “The influence of acetylcholine and taurine on the content of some metabolites in the alga Chlorella vulgaris”, Ecohydrol. Hydrobiol. 3(2), 223–229 (2003).
  13. Fabris, M., Abbriano, R.M., Pernice, M., Sutherland, D.L., Commault, A.S., Hall, C.C., Labeeuw, L., McCauley, J.I., Kuzhiuparambil, U., Ray, P., Kahlke, T., Ralph, P.J.,“Emerging technologies in algal biotechnology: toward the establishment of a sustainable, algae-based bioeconomy”, Front. Plant Sci. 11, 279 (2020). DOI: 10.3389/fpls.202N/D279.
  14. Love, A.C., Travisano, M.,“Microbes modelling ontogeny”, Biol. Philos. 28, 161–188 (2013). DOI: 10.1007/s10539-013-9363-5.
  15. Machado, M., Soares, E.C.S.,“Life and death of Pseudokirchneiella subcapitata: physiological changes during chronological aging”, Appl. Microbiol. Biotechnol. 1066, 8245–8258 (2022). DOI: 10.1007/s00253-022-12267-5.
  16. Oleskin, A.V., Postnov, A.L., Boyang, C., “Impact of biogenic amines on the growth of a Chlorella vulgaris culture”, J. Pharm. Nutr. Sci. 11, 49–53 (2021). DOI: 10.29169/1927-5951.2021.11.07.
  17. Oleskin, A.V., Postnov, A.L., Boyang, C., “Impact of biogenic amines on the growth of green microalgae”, J. Pharm. Nutr. Sci. 11, 144–150 (2021). DOI:10.29169/1927-5951.2021.11.17.
  18. Parsaiemehr, A., Sun, Z., Dou, X., Chen, Y.-F.,“Simultaneous improvement in production of microalgal biodiesel and high-value alpha-linolenic acid by a single regulator acetylcholine”, Biotechnol. Biofuels. 8, 11 (2015). DOI: 10.1186/s13068-015-0196-0.
  19. Piotrowska-Niczyporuk, A., Bajguz, A.,“The effect of natural and synthetic auxins on the growth. metabolite content and antioxidant response of the green alga Chlorella vulgaris (Trebouxiophyceae)”, Plant Growth Regul. 73, 57–66 (2014). DOI: 10.1007/s10725-013-9867-7.
  20. Powell, K., Pharm: The Comprehensive Pharmacology Reference (Amsterdam: Elsevier, 2007. P. 1–2).
  21. Qiu, J., Vadiveloo, A., Mao, B.-D., Zhou, J.-L., Gao, T.,“Phytohormones as a novel strategy for promoting phytoremediation in microalgae: progress and prospects”, J. Environ. Management. 273, 123593 (2025).
  22. Roshchina, V.V., Yashin, V.A., Podunai, Y.A.,“Fluorescence in the study of diatom Ulnaria ulna cells”, Austin Environ. Sci. 7 (3), 107–110 (2022).
  23. Schiechl, G., Himmelsbach, M., Buchberger, W., Kerschbaum, H.H., Lütz-Meindl, U., “Identification of acetylcholine and impact of cholinomimetic drugs on cell differentiation and growth in the unicellular green alga Micrasterias denticulate”, Plant Sci. 175(3), 262–266 (2008). DOI: 10.1016/j.plantsci.2008.04.006.
  24. Solovchenko, A., “Recent breakthroughs in the biology of astaxanthin accumulation by microalgal cells”, Photosynthesis Res. 125(3), 437–449 (2015). DOI: 10.1007/s11120-015-0156-3.
  25. Steffen, P.R., Hedes, D., Matheson, R., “The brain is adaptive not triune: how the brain responds to threat, challenge, and change”, Front. Psychiatr. 13, 802606 (2022). DOI: 10.3389/fpsyt.2022.802606.
  26. Steiner, U.K.,“Senescence in bacteria and its underlying mechanisms”, Front. Cell Dev. Biol. 9, 668915 (2021). DOI: 10.3389/fcell.2021.668915.
  27. Tiwari, S., Patel, A., Prasad, S.M.,“Phytohormone upregulates the biochemical constituent, exopolysaccharide and energy metabolism in paddy-field cyanobacteria exposed to chromium stress”, BMC Microbiol. 20, 206 (2020). DOI: 10.1186/s12866-020-01799-3.
  28. Tredici, M.R., Rodolfi, L., Biondi, N., Bassi, N., Sampietro, G., “Techno-economic analysis of microalgal biomass production in a 1-ha Green Wall Panel (GWP®) plant”, Algal Res. 19, 253–263 (2016). DOI: 10.1016/j.algal.2016.09.005.
  29. Van Alstyne, K.L., Ridgway, R.L., Nelson, A., “Neurotransmitters in marine and freshwater algae”, Neurotransmitters in Plants: Perspectives and Applications (Boca Raton (FL): CRC Press, 2018), 27–36. DOI: 10.1201/b22467-3.
  30. Yu, J., You, X., Gao, Y., Guo, L., Xang, X., Gao, M., Zhao, Y., Jin, C., Ji, J., Che, Z., “The impact of auxin analogs on microalgal intracellular component accumulation and nutrient removal for mariculture wastewater treatment basing on bacterial-algal coupling technology”, Process Safety and Environmental Protection 164, 660–668 (2022).
  31. Zhao, Y., Li, Q., Yang, M., Huang, F., Liu, J., Yu, X., Yu, L., “Exploiting synergy of dopamine and stressful conditions in enhancing Haematococcus lacustris biomass and astaxanthin yield”, Bioresource Technol. 417, 131848 (2025). DOI: 10.1016/j.biotech.2024.131848.
  32. Zhao, C., Lu, B., Wang, Z., Wei, J., Zhao, Y., Wang, S., “Enhanced antibiotics and antibiotics resistance genes removal from aquaculture wastewater by microalgae-based system induced with plant hormones”, Int. Biodeterior. Biodegrad. 200, 106045 (2025). DOI: 10.1016/ j.ibiod.2025.106045.

References

  1. Golovlev, E.L., “Academician N.D. Yerusalimsky”, Microbiology (Moscow) 68(6), 800–808 (in Russian).
  2. Yerusalimsky, N.D., Physiology of Development of Pure Cultures. Dr. Sci. Biol. Thesis (Moscow: Institute of Microbiology of the USSR Academy of Sciences, 1952) (in Russian).
  3. Maryin, V.A., Kharitonov, D.V., “Study on the sequence of growth phases in the batch cultures of bifidobacteria or lactobacteria”, Technique and Technology 19(4) (2010)(in Russian).
  4. Feofilova, E.P., Mysiakina, I.S., Biofuel: problems and prospects (Moscow: National Academy of Mycology, 2016) (in Russian).
  5. Tsavkelova, E.A., Klimova, S.Yu., Cherdyntseva, T.A., Netrusov, A.I., “Microorganisms producing plant growth stimulants: practical applications (a review)”, Appl. Biochem. Microbiol. 42(2), 133–143 (2006) (in Russian).
  6. Tsavkelova, E.A., Klimova, S.Yu., Cherdyntseva, T.A., Netrusov, A.I.,“Hormones and hormone-like compounds of microorganisms (a review)”, Appl. Biochem. Microbiol. 42(3), 261–268 (2006) (in Russian).
  7. Cao, B., Oleskin, A.V.,“Neurochemical pollutants in the aquatic medium: the results of studies with model organisms (microalgae)”, Zhizn Zemli [Life on the Earth] 47(4), 26–40 (2025). DOI: 10.29003/м28.0514-7468.
  8. Cao, B., Chivkunova, O.B., Solovchenko, A.E., Lobakova, E.S., Oleskin, A.V.,“Impact of neurotransmitters on the fatty acid composition and pigments of the green microalga Scenedesmus quadricauda”, Appl. Biochem. Microbiol. 60(5), 833–843 (2024). DOI: 10.1134/S0003683824604554.
  9. Cao, B., Fedorenko, T.A., Chivkunova, O.B., Solovchenko, A.E., Lobakova, E.S., Oleskin, A.V.,“Impact of neurotransmitters on the photosynthetic pigment content of the green microalga Haematococcus lacustris (strains IPPAS H-239 and BM-1)”, Appl. Biochem. Microbiol. 61(5), 865–871 (2025). DOI: 10.1134/S0003683825601155.
  10. Cao, B., Fedorenko, T.A., Chivkunova, O.B., Solovchenko, A.E., Lobakova, E.S., Oleskin, A.V., “Impact of neurotransmitters on biomass accumulation, photosynthetic pigment content, and fatty acid composition of the cyanobacterium Limnospira platensis IPPAS B-256”, Microbiology (Moscow) 95 (1), 82-95 (2026). DOI: 10.1134/S0026261725602921.
  11. Chekanov, K., Lobakova, E., Selyakh, I., Semenova, L., Sidorov, R., Solovchenko, A.,“Accumulation of astaxanthin by a new Haematococcus pluvialis strain BM1 from the White Sea coastal rocks (Russia)”, Mar Drugs. 12(8), 4504–4520 (2014). DOI: 10.3390/md12084504.
  12. Czerpak, R., Bajguz, A., Jewiec, P., Muszynska-Garstka, M., “The influence of acetylcholine and taurine on the content of some metabolites in the alga Chlorella vulgaris”, Ecohydrol. Hydrobiol. 3(2), 223–229 (2003).
  13. Fabris, M., Abbriano, R.M., Pernice, M., Sutherland, D.L., Commault, A.S., Hall, C.C., Labeeuw, L., McCauley, J.I., Kuzhiuparambil, U., Ray, P., Kahlke, T., Ralph, P.J.,“Emerging technologies in algal biotechnology: toward the establishment of a sustainable, algae-based bioeconomy”, Front. Plant Sci. 11, 279 (2020). DOI: 10.3389/fpls.202N/D279.
  14. Love, A.C., Travisano, M.,“Microbes modelling ontogeny”, Biol. Philos. 28, 161–188 (2013). DOI: 10.1007/s10539-013-9363-5.
  15. Machado, M., Soares, E.C.S.,“Life and death of Pseudokirchneiella subcapitata: physiological changes during chronological aging”, Appl. Microbiol. Biotechnol. 1066, 8245–8258 (2022). DOI: 10.1007/s00253-022-12267-5.
  16. Oleskin, A.V., Postnov, A.L., Boyang, C., “Impact of biogenic amines on the growth of a Chlorella vulgaris culture”, J. Pharm. Nutr. Sci. 11, 49–53 (2021). DOI: 10.29169/1927-5951.2021.11.07.
  17. Oleskin, A.V., Postnov, A.L., Boyang, C., “Impact of biogenic amines on the growth of green microalgae”, J. Pharm. Nutr. Sci. 11, 144–150 (2021). DOI:10.29169/1927-5951.2021.11.17.
  18. Parsaiemehr, A., Sun, Z., Dou, X., Chen, Y.-F.,“Simultaneous improvement in production of microalgal biodiesel and high-value alpha-linolenic acid by a single regulator acetylcholine”, Biotechnol. Biofuels. 8, 11 (2015). DOI: 10.1186/s13068-015-0196-0.
  19. Piotrowska-Niczyporuk, A., Bajguz, A.,“The effect of natural and synthetic auxins on the growth. metabolite content and antioxidant response of the green alga Chlorella vulgaris (Trebouxiophyceae)”, Plant Growth Regul. 73, 57–66 (2014). DOI: 10.1007/s10725-013-9867-7.
  20. Powell, K., Pharm: The Comprehensive Pharmacology Reference (Amsterdam: Elsevier, 2007. P. 1–2).
  21. Qiu, J., Vadiveloo, A., Mao, B.-D., Zhou, J.-L., Gao, T.,“Phytohormones as a novel strategy for promoting phytoremediation in microalgae: progress and prospects”, J. Environ. Management. 273, 123593 (2025).
  22. Roshchina, V.V., Yashin, V.A., Podunai, Y.A.,“Fluorescence in the study of diatom Ulnaria ulna cells”, Austin Environ. Sci. 7 (3), 107–110 (2022).
  23. Schiechl, G., Himmelsbach, M., Buchberger, W., Kerschbaum, H.H., Lütz-Meindl, U., “Identification of acetylcholine and impact of cholinomimetic drugs on cell differentiation and growth in the unicellular green alga Micrasterias denticulate”, Plant Sci. 175(3), 262–266 (2008). DOI: 10.1016/j.plantsci.2008.04.006.
  24. Solovchenko, A., “Recent breakthroughs in the biology of astaxanthin accumulation by microalgal cells”, Photosynthesis Res. 125(3), 437–449 (2015). DOI: 10.1007/s11120-015-0156-3.
  25. Steffen, P.R., Hedes, D., Matheson, R., “The brain is adaptive not triune: how the brain responds to threat, challenge, and change”, Front. Psychiatr. 13, 802606 (2022). DOI: 10.3389/fpsyt.2022.802606.
  26. Steiner, U.K.,“Senescence in bacteria and its underlying mechanisms”, Front. Cell Dev. Biol. 9, 668915 (2021). DOI: 10.3389/fcell.2021.668915.
  27. Tiwari, S., Patel, A., Prasad, S.M.,“Phytohormone upregulates the biochemical constituent, exopolysaccharide and energy metabolism in paddy-field cyanobacteria exposed to chromium stress”, BMC Microbiol. 20, 206 (2020). DOI: 10.1186/s12866-020-01799-3.
  28. Tredici, M.R., Rodolfi, L., Biondi, N., Bassi, N., Sampietro, G., “Techno-economic analysis of microalgal biomass production in a 1-ha Green Wall Panel (GWP®) plant”, Algal Res. 19, 253–263 (2016). DOI: 10.1016/j.algal.2016.09.005.
  29. Van Alstyne, K.L., Ridgway, R.L., Nelson, A., “Neurotransmitters in marine and freshwater algae”, Neurotransmitters in Plants: Perspectives and Applications (Boca Raton (FL): CRC Press, 2018), 27–36. DOI: 10.1201/b22467-3.
  30. Yu, J., You, X., Gao, Y., Guo, L., Xang, X., Gao, M., Zhao, Y., Jin, C., Ji, J., Che, Z., “The impact of auxin analogs on microalgal intracellular component accumulation and nutrient removal for mariculture wastewater treatment basing on bacterial-algal coupling technology”, Process Safety and Environmental Protection 164, 660–668 (2022).
  31. Zhao, Y., Li, Q., Yang, M., Huang, F., Liu, J., Yu, X., Yu, L., “Exploiting synergy of dopamine and stressful conditions in enhancing Haematococcus lacustris biomass and astaxanthin yield”, Bioresource Technol. 417, 131848 (2025). DOI: 10.1016/j.biotech.2024.131848.
  32. Zhao, C., Lu, B., Wang, Z., Wei, J., Zhao, Y., Wang, S., “Enhanced antibiotics and antibiotics resistance genes removal from aquaculture wastewater by microalgae-based system induced with plant hormones”, Int. Biodeterior. Biodegrad. 200, 106045 (2025). DOI: 10.1016/ j.ibiod.2025.106045.