For the first time in the research literature, the paper highlights the cooperation of the outstanding Russian investigators G.N. Potanin (1835–1920) and V.I. Vernadsky (1863–1945). The basis of interaction between these scientists was determined by the fact that both of them were students of Natural Department of the Faculty of Physics and Mathematics of Imperial St. Petersburg University. They carried the knowledge and interest in research gained at the university throughout their lives. Based on authentic sources, the authors revealed the role of A.A. Inostrantsev (1843–1919) as the organizer and ruler of the geological cabinet (museum) at St. Petersburg University, where G.N. Potanin acquired the necessary knowledge for his scientific expeditions to Central Asia in 1874. Under the influence of Dr. Inostrantsev, Potanin realized the importance of museums in geology and other branches. Besides, he supported V.V. Dokuchaev (1846–1903) in conducting soil science research in Russia. The paper emphasizes the participation of the university student Vladimir Vernadsky in Prof. Dokuchaev’s expeditions and in the preparation of a soil exposition at the World Exhibition in Paris in 1889. Following in the footsteps of his teachers and mentors, V.I. Vernadsky joined the museum science, became the curator of the Mineralogical Museum in Alma Mater, and then, some years later, in the Imperial Moscow University.
Immediate communication between V.I. Vernadsky and G.N. Potanin occurred in the 1890s – 1900s, when they participated in discussions on ideological and political reorganization of Russia, pondered on the problems of regional self-government in the country. As a brief conclusion from this publication, the authors postulate free thought and scientific creativity, which related to Vernadsky and Potanin, as relevant ideas of our days.