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Zhizn Zemli [Life of the Earth] 47, no 4
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Zhizn Zemli [Life of the Earth] 47, no 4

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10.29003/m4988.0514-7468.2025_47_4/550-562

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Authors:

Cao Boyang, Oleskin, A.V.

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Keywords:

ecotoxicants, pharmaceuticals, neurotransmitters, serotonin, histamine, norepinephrine, dopamine, acetylcholine, microalgae, eutrophication.

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Cao, Boyang, Oleskin, A.V., “Neurochemical pollutants in the aquatic medium: the results of studies with model organisms (microalgae)”, Zhizn Zemli [Life of the Earth] 47, no 4, 550–562 (2025) (in Engl., abstr. in Russ.). DOI: 10.29003/m4988.0514-7468.2025_47_4/550-562.

Neurochemical pollutants in the aquatic medium: the results of studies with model organisms (microalgae)

The constantly extending list of humankind-produced environmentally toxic compounds currently includes pharmacological preparations. Among them, of potential relevance are neurotransmitters including such biogenic amines as norepinephrine, dopamine, serotonin, and histamine, as well as acetylcholine. These neurotransmitters were tested in the present work using such model organisms as the green microalgae Chlorella vulgaris Beijer, Scenedesmus quadricauda (Turp.) Breb. К-1149, and Haematococcus lacustris (= pluvialis) strains IPPAS H-239 and BM-1, as well as the cyanobacterium Limnospira platensis IPPAS B-256. It was established that all tested neurotransmitters significantly stimulate the growth of the cultures of microalgae at sufficiently low (micromolar) concentrations. In light of the results of this work, uncontrollable microalgal growth seems to be possible under the influence of trace amounts of neurotransmitters in natural and artificial water bodies, which might cause their eutrophication. All tested substances influenced the photosynthetic pigment content at micromolar (or submicromolar) concentrations, acetylcholine being a quasi-universal promoter of their biosynthesis that presumably stimulates the photosynthetic activity of the microalgae. The effects of the other tested substances varied depending on the microalgal species involved but predominantly resulted in promoting photosynthetic pigment biosynthesis. A biotechnological project aimed at stimulating the microalgal biomass yield by supplementing microalgal cultures with neurotransmitters seems to hold promise for producing drugs, food additives, or biofuel.

Список литературы

  1. Buznikov, G.A., Neurotransmitters in Embryogenesis (Moscow: Nauka, 1987) (in Russian).
  2. Buznikov, G.A., “Preneural transmitters as embryogenesis regulators”, Ontogenez [Ontogeny] 38 (4), 262–270 (2007) (in Russian).
  3. Dubynin, V.A., Kamensky, A.A., Sapin M.R., Sivoglazov, V.N., Regulatory Systems of the Human Organism (Moscow: Drofa, 2010) (in Russian).
  4. Lifshits, V.M., Sidel’nikova, V.I., Laboratory Tests for Healthy People. Reference Values (Moscow: Triada-X, 2004) (in Russian).
  5. Matvienko, T.I., Fundamentals of Toxicology. A Course of Lectures (Khabarovsk: TOGU Publ., 2006) (in Russian).
  6. Oleskin, A.V., “Interaction of neurotransmitters with microorganisms: implications for aquatic ecosystems”, Priroda [Nature] 6, 61–74 (2024). DOI: 10.7868/S0032874X24070077 (in Russian).
  7. Oleskin, A.V., Postnov, A.L., “Neurotransmitters as communicative agents in aquatic ecosystems”, Vestn. Mos. Un-ta. Ser. 16 (Biology) [Mos. Univ. Bull.] 77 (1), 9–15 (2022). DOI: 10.31857/S0555109922060125 (in Russian).
  8. Oleskin, A.V., Shenderov, B.A., Rogovsky, V.S., Microbial Sociality and Interaction in the Microbiota-Host System: the Role of Neurotransmitters (Moscow: Moscow University Publishing Co., 2020) (in Russian).
  9. Roschina, V.V., Biomediators in Plants: Acetylcholine and Biogenic Amines (Puschino: NTS, 1991) (in Russian).
  10. Roschina, V.V., Neurotransmitters as Biomediators and Regulators in Plants (Moscow: Informika, 2010) (in Russian).
  11. Tsavkelova, E.A., Klimova, S.Yu., Cherdyntseva, T.A., Netrusov, A.I. “Hormones and hormone-like compounds of microorganisms (a review)”, Appl. Biochem. Microbiol. 42(3) 261-268 (2006).
  12. Cao, B., Chivkunova, O.B., Solovchenko, A.E., Lobakova, E.S., Oleskin, A.V., “Impact of neurotransmitters on the fatty acid composition and pigments of the green microalga Scenedesmus quadricauda”, Appl. Biochem. Microbiol. 60 (5) 833–843 (2024). DOI: 10.31857/S0555109924050064.
  13. Cao, B., Fedorenko, T.A., Chivkunova, O.B., Solovchenko, A.E., Lobakova, E.S., Oleskin, A.V. “Impact of neurotransmitters on the photosynthetic pigment content of the green microalga Haematococcus lacustris (strains IPPAS H-239 and BM-1)”, Appl. Biochem. Microbiol. 61 (5) 865–871 (2025). DOI: 10.1134/S0003683825601155.
  14. Alsenani, F., Wass, T.J., Ma, R., Eltahany, E., Netzel, M.E., Schenk, P.M., “Transcriptome-wide analysis of Chlorella reveals auxin-induced carotenogenesis pathway in green microalgae”, Algal Res. 37, 320–335 (2019). DOI: 10.1016/j.algal.2018.12.002.
  15. Aydin, S., Ulvi, A., Bedük, F., Aydin, M.E., “Pharmaceutical residues in digested sewage sludge: occurrence, seasonal variation and risk assessment for soil”, Sci. Total Environ. 817 152864 (2022). DOI: 10.1016/j.scitotenv.2021.152864.
  16. Chakraborty, A., Adhikary, S., Bhattacharya, S., Dutta, S., Chatterjee, S., Banerjee, D., Ganguly, A., Rajak, P., “Pharmaceutical and personal care products as emerging environmental contaminants: prevalence, toxicity, and remedial approaches”, ACS Chem. Health Safety 30 (6), 362–388 (2023). DOI: 10.1021/acs.chas. 3c0071.
  17. Eldrup, E., “Significance and origin of DOPA, DOPAC and dopamine-sulfate in plasma, tissue and cerebrospinal fluid”, Dan. Med. Bull 31, 34–62 (2004).
  18. Fick, J., Lindberg, R.H., Parkhonen, J., Arvidsson, B., Tysklind, M., Larsson, D.J., “Therapeutic levels of levonorgestrel detected in blood plasma of fish: results from screening rainbow trout exposed to treated sewage effluents”, Environ. Sci. Technol. 44 (7), 2661–2666 (2010). DOI: 10.1021/es903440m.
  19. Issa, S., Gamelon, M., Cisielski, T.M., Vike-Jones, K., Asimakopoulos, A.G., Jaspers, V.L.B., Einum, S., “Dopamine mediates life-history responses to food abundance in Daphnia”, P Roy. Soc. B-Biol. Sci. 287 (1930) 20201069 (2020). DOI: 10.1098/rspb.2020.1069.
  20. Kay, P., Hughis, S.R., Ault, J.R., Ashcroft, A.E., Brown, L.E., “Widespread routine occurrence of pharmaceuticals in sewage effluent, combined sewer outflows and receiving waters”, Environ. Pollution 220 (Pt. B), 1447–1455 (2017). DOI: 10.1016/j.envpol.2016.10.087.
  21. Learn, J.R., “Some rivers are so drug-polluted, their eels get high on cocaine”, National Geographic, 2018 (https://www.nationalgeographic.co.uk).
  22. Mudgal, S., De Toni, A., Lockwood, S., Backhaus, K., Sorensen, B., Study on the environmental risks of medicinal products: final report (Luxembourg City: Executive Agency for Health and Consumers, 2013).
  23. Oleskin, A.V., Postnov, A.L., Cao, B., “Impact of biogenic amines on the growth of green microalgae”, J. Pharm. Nutr. Sci. 11, 144–150 (2021). DOI: 10.29169/1927-5951.2021.11.17.
  24. Oleskin, A.V., Postnov, A.L., Cao, B., “Impact of biogenic amines on the growth of a Chlorella vulgaris culture”, J. Pharm. Nutr. Sci. 11, 49–53 (2021). DOI: 10.29169/1927-5951.2021.11.07.
  25. Qiu, J., Vadiveloo, A., Mao, B.-D., Zhou, J.-L., Gao, T. “Phytohormones as a novel strategy for promoting phytoremediation in microalgae: progress and prospects”, J. Environ. Manag. 273 123593. DOI: 10.1016/j.jenvman.2024.123593.
  26. Ramakrishna, R, Mukherjee, S., “New insights on neurotransmitter signaling mechanisms in plants”, Plant Signal Behav. 15 (6), 1737450. DOI: 10.1080/1559232420201737450.
  27. Roshchina, V.V., “Evolutionary considerations of neurotransmitters in microbial, plant, and animal cells”, Microbial endocrinology: Interkingdom Signaling in Infectious Disease and Health (New York: Springer, 2010).
  28. Roshchina, V.V., Prizova, N.K., Khaibulaeva, L.M., “Allelopathy experiments with Chara algae model: Histochemical analysis of the participation of neurotransmitter systems in water inhabitation”, Allelopathy J. 46 (1), 17–24 (2019). DOI: 10.26651/allelo.j/2019-46-1-1195.
  29. Roshchina, V.V., Yashin, V.A., Podunai Y.A., “Fluorescence in the study of diatom Ulnaria ulna cells”, Austin Environ. Sci. 7 (3), 107–110.
  30. Sehonova, P., Svobodova, Z., Dolezelova, P., Vosmerova, P., Faggio, C., “Effects of waterborne antidepressants on non-target animals living in the aquatic environment: a review”, Sci. Tot. Env. 631-632, 789–794. DOI: 10.1016/j.scitotenv2018.03.076.
  31. Van Alstyne, K.L., Ridgway, R.L., Nelson, A., “Neurotransmitters in marine and freshwater algae”, Neurotransmitters in Plants: Perspectives and Applications (Boca Raton (FL): CRC Press, 2018) 27–36. DOI: 10.1201/b22467-3.
  32. Wang, J., Wang, S., “Removal of pharmaceuticals and personal care products (PPCPs) from wastewater: A review”, J. Environ. Manag. 182, 620–640. DOI: 10.1016/j.jenvman.2016.07.049.
  33. Zhao, Z., Yang, H., Feng, Z., Huo, Y., Fu, L., Zhou, D., “Role of naphthaleneacetic acid in the degradation of bisphenol A and wastewater treatment by microalgae: enhancement and signaling”, Chemosphere 307. P.135829. DOI: 10.1016/j.chemosphere.2022.135829.

References

  1. Buznikov, G.A., Neurotransmitters in Embryogenesis (Moscow: Nauka, 1987) (in Russian).
  2. Buznikov, G.A., “Preneural transmitters as embryogenesis regulators”, Ontogenez [Ontogeny] 38 (4), 262–270 (2007) (in Russian).
  3. Dubynin, V.A., Kamensky, A.A., Sapin M.R., Sivoglazov, V.N., Regulatory Systems of the Human Organism (Moscow: Drofa, 2010) (in Russian).
  4. Lifshits, V.M., Sidel’nikova, V.I., Laboratory Tests for Healthy People. Reference Values (Moscow: Triada-X, 2004) (in Russian).
  5. Matvienko, T.I., Fundamentals of Toxicology. A Course of Lectures (Khabarovsk: TOGU Publ., 2006) (in Russian).
  6. Oleskin, A.V., “Interaction of neurotransmitters with microorganisms: implications for aquatic ecosystems”, Priroda [Nature] 6, 61–74 (2024). DOI: 10.7868/S0032874X24070077 (in Russian).
  7. Oleskin, A.V., Postnov, A.L., “Neurotransmitters as communicative agents in aquatic ecosystems”, Vestn. Mos. Un-ta. Ser. 16 (Biology) [Mos. Univ. Bull.] 77 (1), 9–15 (2022). DOI: 10.31857/S0555109922060125 (in Russian).
  8. Oleskin, A.V., Shenderov, B.A., Rogovsky, V.S., Microbial Sociality and Interaction in the Microbiota-Host System: the Role of Neurotransmitters (Moscow: Moscow University Publishing Co., 2020) (in Russian).
  9. Roschina, V.V., Biomediators in Plants: Acetylcholine and Biogenic Amines (Puschino: NTS, 1991) (in Russian).
  10. Roschina, V.V., Neurotransmitters as Biomediators and Regulators in Plants (Moscow: Informika, 2010) (in Russian).
  11. Tsavkelova, E.A., Klimova, S.Yu., Cherdyntseva, T.A., Netrusov, A.I. “Hormones and hormone-like compounds of microorganisms (a review)”, Appl. Biochem. Microbiol. 42(3) 261-268 (2006).
  12. Cao, B., Chivkunova, O.B., Solovchenko, A.E., Lobakova, E.S., Oleskin, A.V., “Impact of neurotransmitters on the fatty acid composition and pigments of the green microalga Scenedesmus quadricauda”, Appl. Biochem. Microbiol. 60 (5) 833–843 (2024). DOI: 10.31857/S0555109924050064.
  13. Cao, B., Fedorenko, T.A., Chivkunova, O.B., Solovchenko, A.E., Lobakova, E.S., Oleskin, A.V. “Impact of neurotransmitters on the photosynthetic pigment content of the green microalga Haematococcus lacustris (strains IPPAS H-239 and BM-1)”, Appl. Biochem. Microbiol. 61 (5) 865–871 (2025). DOI: 10.1134/S0003683825601155.
  14. Alsenani, F., Wass, T.J., Ma, R., Eltahany, E., Netzel, M.E., Schenk, P.M., “Transcriptome-wide analysis of Chlorella reveals auxin-induced carotenogenesis pathway in green microalgae”, Algal Res. 37, 320–335 (2019). DOI: 10.1016/j.algal.2018.12.002.
  15. Aydin, S., Ulvi, A., Bedük, F., Aydin, M.E., “Pharmaceutical residues in digested sewage sludge: occurrence, seasonal variation and risk assessment for soil”, Sci. Total Environ. 817 152864 (2022). DOI: 10.1016/j.scitotenv.2021.152864.
  16. Chakraborty, A., Adhikary, S., Bhattacharya, S., Dutta, S., Chatterjee, S., Banerjee, D., Ganguly, A., Rajak, P., “Pharmaceutical and personal care products as emerging environmental contaminants: prevalence, toxicity, and remedial approaches”, ACS Chem. Health Safety 30 (6), 362–388 (2023). DOI: 10.1021/acs.chas. 3c0071.
  17. Eldrup, E., “Significance and origin of DOPA, DOPAC and dopamine-sulfate in plasma, tissue and cerebrospinal fluid”, Dan. Med. Bull 31, 34–62 (2004).
  18. Fick, J., Lindberg, R.H., Parkhonen, J., Arvidsson, B., Tysklind, M., Larsson, D.J., “Therapeutic levels of levonorgestrel detected in blood plasma of fish: results from screening rainbow trout exposed to treated sewage effluents”, Environ. Sci. Technol. 44 (7), 2661–2666 (2010). DOI: 10.1021/es903440m.
  19. Issa, S., Gamelon, M., Cisielski, T.M., Vike-Jones, K., Asimakopoulos, A.G., Jaspers, V.L.B., Einum, S., “Dopamine mediates life-history responses to food abundance in Daphnia”, P Roy. Soc. B-Biol. Sci. 287 (1930) 20201069 (2020). DOI: 10.1098/rspb.2020.1069.
  20. Kay, P., Hughis, S.R., Ault, J.R., Ashcroft, A.E., Brown, L.E., “Widespread routine occurrence of pharmaceuticals in sewage effluent, combined sewer outflows and receiving waters”, Environ. Pollution 220 (Pt. B), 1447–1455 (2017). DOI: 10.1016/j.envpol.2016.10.087.
  21. Learn, J.R., “Some rivers are so drug-polluted, their eels get high on cocaine”, National Geographic, 2018 (https://www.nationalgeographic.co.uk).
  22. Mudgal, S., De Toni, A., Lockwood, S., Backhaus, K., Sorensen, B., Study on the environmental risks of medicinal products: final report (Luxembourg City: Executive Agency for Health and Consumers, 2013).
  23. Oleskin, A.V., Postnov, A.L., Cao, B., “Impact of biogenic amines on the growth of green microalgae”, J. Pharm. Nutr. Sci. 11, 144–150 (2021). DOI: 10.29169/1927-5951.2021.11.17.
  24. Oleskin, A.V., Postnov, A.L., Cao, B., “Impact of biogenic amines on the growth of a Chlorella vulgaris culture”, J. Pharm. Nutr. Sci. 11, 49–53 (2021). DOI: 10.29169/1927-5951.2021.11.07.
  25. Qiu, J., Vadiveloo, A., Mao, B.-D., Zhou, J.-L., Gao, T. “Phytohormones as a novel strategy for promoting phytoremediation in microalgae: progress and prospects”, J. Environ. Manag. 273 123593. DOI: 10.1016/j.jenvman.2024.123593.
  26. Ramakrishna, R, Mukherjee, S., “New insights on neurotransmitter signaling mechanisms in plants”, Plant Signal Behav. 15 (6), 1737450. DOI: 10.1080/1559232420201737450.
  27. Roshchina, V.V., “Evolutionary considerations of neurotransmitters in microbial, plant, and animal cells”, Microbial endocrinology: Interkingdom Signaling in Infectious Disease and Health (New York: Springer, 2010).
  28. Roshchina, V.V., Prizova, N.K., Khaibulaeva, L.M., “Allelopathy experiments with Chara algae model: Histochemical analysis of the participation of neurotransmitter systems in water inhabitation”, Allelopathy J. 46 (1), 17–24 (2019). DOI: 10.26651/allelo.j/2019-46-1-1195.
  29. Roshchina, V.V., Yashin, V.A., Podunai Y.A., “Fluorescence in the study of diatom Ulnaria ulna cells”, Austin Environ. Sci. 7 (3), 107–110.
  30. Sehonova, P., Svobodova, Z., Dolezelova, P., Vosmerova, P., Faggio, C., “Effects of waterborne antidepressants on non-target animals living in the aquatic environment: a review”, Sci. Tot. Env. 631-632, 789–794. DOI: 10.1016/j.scitotenv2018.03.076.
  31. Van Alstyne, K.L., Ridgway, R.L., Nelson, A., “Neurotransmitters in marine and freshwater algae”, Neurotransmitters in Plants: Perspectives and Applications (Boca Raton (FL): CRC Press, 2018) 27–36. DOI: 10.1201/b22467-3.
  32. Wang, J., Wang, S., “Removal of pharmaceuticals and personal care products (PPCPs) from wastewater: A review”, J. Environ. Manag. 182, 620–640. DOI: 10.1016/j.jenvman.2016.07.049.
  33. Zhao, Z., Yang, H., Feng, Z., Huo, Y., Fu, L., Zhou, D., “Role of naphthaleneacetic acid in the degradation of bisphenol A and wastewater treatment by microalgae: enhancement and signaling”, Chemosphere 307. P.135829. DOI: 10.1016/j.chemosphere.2022.135829.